Predicted interaction scores summarize how strongly a paralog pair is expected to show a synthetic lethal dependency in a given cell line. Higher values indicate stronger predicted dependencies.
Differential z-scores show how unusually high a score is for a cell line relative to the same pair across all cell lines, highlighting cell-line-specific effects.
Disease-specific dependencies compare mean pair scores in cell lines of one disease against all other cell lines. Pairs shown are higher in the disease (mean prediction-score difference > 0.1) and significant by a two-sided Welch's t-test after Benjamini-Hochberg correction (FDR < 20%). The estimated FDR (q-value) is reported for each pair.